Abstract
Vigabatrin was given as first-line therapy in 29 children with infantile spasms (IS). Vigabatrin monotherapy achieved complete control of spasms without subsequent relapse in 45% of patients. In all other patients, response was Partial or relapse occurred, and in these patients add-on therapy with tetracosactrin and/or clonazepam achieved a complete response. Side-effects with vigabatrin were mild and transient, and occurred in only four patients. The complete responses observed with vigabatrin occurred a short time after initiating treatment. These data further support the high efficacy of vigabatrin as first-line monotherapy for the treatment of IS.
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