Abstract
It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et al., 1993). Since then, several studies have replicated the effects of dietary methionine restricted (MR) in delaying age-related diseases (Richie et al., 1994; Miller et al., 2005; Ables et al., 2012; Sanchez-Roman and Barja, 2013). We report the abstracts from the First International Mini-Symposium on Methionine Restriction and Lifespan held in Tarrytown, NY, September 2013. The goals were (1) to gather researchers with an interest in MR and lifespan, (2) to exchange knowledge, (3) to generate ideas for future investigations, and (4) to strengthen relationships within this community. The presentations highlighted the importance of research on cysteine, growth hormone (GH), and ATF4 in the paradigm of aging. In addition, the effects of dietary restriction or MR in the kidneys, liver, bones, and the adipose tissue were discussed. The symposium also emphasized the value of other species, e.g., the naked mole rat, Brandt's bat, and Drosophila, in aging research. Overall, the symposium consolidated scientists with similar research interests and provided opportunities to conduct future collaborative studies (Figure 3).
Highlights
We report the abstracts from the First International Mini-Symposium on Methionine Restriction and Lifespan held inTarrytown, NY, September 2013.The goals were (1) to gather researchers with an interest in methionine restricted (MR) and lifespan, (2) to exchange knowledge, (3) to generate ideas for future investigations, and (4) to strengthen relationships within this community
Stipanuk (Cornell University, USA) presented “Regulation of cysteine dioxygenase (CDO) in response to sulfur amino acid intake: is minimizing H2S production the goal?” The sulfur of sulfur-containing amino acids eventually makes its way to inorganic sulfur or taurine as metabolic end-products that can be excreted in the urine
Cysteine flux through these pathways is a function primarily of the activity of CDO, which initiates the flux of cysteine through the direct oxidative pathway, and of cysteine concentration, which is a large determinant of flux through desulfhydration pathways as well as of CDO abundance and activity
Summary
Restricting Met in rodent diets has been shown to lower insulin-like growth factor-1 (IGF-1) and extend lifespan. Underlying GH status influenced the metabolic responses to altered dietary Met. Lifespan studies using Ames dwarf and GH transgenic animals subjected to diets restricted or enriched with Met are currently underway.
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