Abstract
The First Human Immunotherapy Trial with a Viral Oncolysate Vaccine Induced a Large Number of Granular Lymphocytes Later Recognized as 'Natural Killer Cells'
Highlights
The First Human Immunotherapy Trial with a Viral Oncolysate Vaccine Induced a Large Number of Granular Lymphocytes Later Recognized as ‘Natural Killer Cells’
Autologous or allogeneic human tumor cells with small compact T lymphocytes attached to them, died mainly with nuclear clumping; some tumor cells died in cytoplasmic lysis
The control buffy coat lymphocytes were provided by the healthy donor
Summary
The First Human Immunotherapy Trial with a Viral Oncolysate Vaccine Induced a Large Number of Granular Lymphocytes Later Recognized as ‘Natural Killer Cells’. The first visualization (and photographic records) of what has become known much later as human “natural killer cells” (NK) was initiated in 1969 at the Section of Clinical Tumor Virology and Immunology, Department of Medicine, The University of Texas M.D. Anderson Hospital, Houston TX [1]. Autologous or allogeneic human tumor cells (first sarcoma cells; later melanoma cells; later adenocarcinoma cells) with small compact T lymphocytes attached to them, died mainly with nuclear clumping (later discovered elsewhere as “apoptosis”); some tumor cells died in cytoplasmic lysis.
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