Abstract
The first human clinical study for NMN has started in Japan.
Highlights
In the recently published review in npj Aging and Mechanisms of Disease, Imai and Guarente[1] have provided a stimulating review about the role of nicotinamide adenine dinucleotide (NAD) in aging
Dietary restriction and exercise appear to be the realistic interventions, but both requires modest lifestyle modification which may be difficult for some individuals to implement. mechanistic target of rapamycin (mTOR) inbibitors, as well as telomere modifiers, can be good practical targets, but they are still under investigation
Metformin and acarbose are considered to be possible anti-aging drugs which are ready for a clinical trial in the US.[4]
Summary
In the recently published review in npj Aging and Mechanisms of Disease, Imai and Guarente[1] have provided a stimulating review about the role of nicotinamide adenine dinucleotide (NAD) in aging. Sir[2] family proteins, called sirtuins, and NAD have attracted researchers’ significant attention for the intervention to promote longevity. As in tango, both sirtuins and NAD are necessary for healthy aging and longevity.
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