Abstract
Calcined Mg-Al Hydrotalcites x = 0.20, 0.27, 0.33 proved effective catalysts for the lactonization of 10, 12, 15, and 16 hydroxy acid benzotriazole esters to their correspondent macrolactones. This new methodology was used for the lactonization step in the synthesis of Sansalvamide A.
Highlights
Macrolactones[1] can be prepared indirectly in very good yields by intramolecular condensation of the ω-hydroxy acids.[2]
This paper presents a new protocol based on the use of synthetic hydrotalcites [M2+1-xM3+x(OH)2]x+[An-x/nmH2O]x, which are hydrated aluminium-magnesium hydroxides of lamellar structure, in which the excess of positive charge, originated from the Mg2+ to Al3+ substitution, is compensated by carbonate anions in the interlayer space
As a part of our on going research program on the utilization of hydrotalcites for organic syntheses, we describe a novel and efficient lactonization procedure for ω-hydroxy acid benzotriazole esters using AlMgCO3-HT with different Mg2+/Al3+ ratios
Summary
Macrolactones[1] can be prepared indirectly in very good yields by intramolecular condensation of the ω-hydroxy acids.[2]. Macrolactones[1] can be prepared indirectly in very good yields by intramolecular condensation of the ω-hydroxy acids.[2] A very practical method for macrolactonization was described by E. As a part of our on going research program on the utilization of hydrotalcites for organic syntheses, we describe a novel and efficient lactonization procedure for ω-hydroxy acid benzotriazole esters using AlMgCO3-HT with different Mg2+/Al3+ ratios.
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