Abstract
Simple SummarySerum levels of MGP, Gas6, vitamin K1, and EGFR were not significantly changed in response to the first cycle of chemotherapy. We found a strong correlation between MGP and VitK1 serum values, and a moderate negative correlation between VitK1 and EGFR in pre-treatment patients. The post-treatment value of EGFR is a strong independent factor that correlates positively with the Gas6 post-treatment values.Background: Vitamin K-dependent proteins (VKDPs) and the epidermal growth factor receptor (EGFR) are involved in lung cancer progression. Therefore, we aimed to study the serum concentration of Matrix Gla protein (MGP), Growth Arrest-specific 6 (Gas6), and EGFR before and after the first cycle of chemotherapy and to investigate how MGP, Gas6, and EGFR are modified after one cycle of chemotherapy. Methods: We performed an observational study on twenty patients diagnosed with lung cancer, by assessing the serum concentration of vitaminK1 (VitK1), MGP, Gas6, and EGFR using the ELISA technique before and after three weeks of the first cycle of chemotherapy. Patients were evaluated using RECIST 1.1 criteria. Results: Serum levels of MGP, Gas6, EGFR, and VK1 before and after treatment were not changed significantly. Regarding the pre-treatment correlation of the MGP values, we found a strong positive relationship between MGP and VK1 pre-treatment values (r = 0.821, 95%CI 0.523; 0.954, p < 0.001). Furthermore, there was a moderately negative correlation between VK1 and EGFR pre-treatment values, with the relationship between them being marginally significant (r = −0.430, 95%CI −0.772; 0.001, p = 0.058). Post-treatment, we found a strong positive relationship between MGP and VK1 post-treatment values (r = 0.758, 95%CI 0.436; 0.900, p < 0.001). We also found a moderate positive relationship between Gas6 and EGFR post-treatment values, but the correlation was only marginally significant (r = 0.442, p = 0.051).
Highlights
The deaths caused by lung cancer represented about 18% of the total number of deaths worldwide in 2020, for both sexes and all ages
Considering the role of these three molecules in lung cancer pathology, the main goal of this study was to assess their serum concentration before and after treatment and investigate how Matrix Gla protein (MGP), Growth Arrest-specific 6 (Gas6), epidermal growth factor receptor (EGFR), and VK1 are modified after one cycle of chemotherapy
Our results showed that the independent factors that influenced the Gas6 values after treatment were MGP and EGFR
Summary
The deaths caused by lung cancer represented about 18% of the total number of deaths worldwide in 2020, for both sexes and all ages. Originating in the bronchial mucous glands, ADC is the most common type of NSCLC, representing the most common subtype of lung cancer in non-smokers [7]. Vitamin K-dependent proteins (VKDPs) and the epidermal growth factor receptor (EGFR) are involved in lung cancer progression. Methods: We performed an observational study on twenty patients diagnosed with lung cancer, by assessing the serum concentration of vitaminK1 (VitK1 ), MGP, Gas, and EGFR using the ELISA technique before and after three weeks of the first cycle of chemotherapy. There was a moderately negative correlation between VK1 and EGFR pre-treatment values, with the relationship between them being marginally significant (r = −0.430, 95%CI −0.772; 0.001, p = 0.058). We found a moderate positive relationship between Gas and EGFR post-treatment values, but the correlation was only marginally significant (r = 0.442, p = 0.051)
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