The first A-nor-hippuristanol and two novel 4,5-secosuberosanoids from the Gorgonian Isis hippuris

Abstract

The first A-nor-hippuristanol, A-nor-22- epi-hippurin-2α-carboxylic acid ( 1 ), and two 4,5-secosuberosane sesquiterpenoids, isishippuric acids A and B ( 2 and 3 ), have been isolated from the gorgonian coral Isis hippuris. Those structures were deduced by extensive 1D and 2D NMR studies. The structure of 1 was further supported by a single crystal X-ray diffraction analysis. Isishippuric acid B has been shown to exhibit potent cytotoxicity toward a limited panel of cancer cells.