Abstract
The Fiocruz Latest Contribution for Understanding Human Tuberculosis Vaccine Development and its Pathogenesis
Highlights
Based on 2012 WHO global report, tuberculosis (TB) is a major cause of illness and death worldwide, with increased burden mainly in developing countries
Mycobacterium bovis bacillus Calmette– Guérin (BCG), the only licensed TB vaccine currently in use, was first administered orally in 1921, and since many clinical trials in different parts of the world have evaluated the effectiveness of BCG in preventing TB disease
The Moreau BCG strain has been employed for some 70 years here in Brazil and lessons from its use should be taken in account for the development or improvement of new TB vaccines
Summary
Based on 2012 WHO global report, tuberculosis (TB) is a major cause of illness and death worldwide, with increased burden mainly in developing countries. The Fiocruz Latest Contribution for Understanding Human Tuberculosis Vaccine Development and its Pathogenesis The Moreau BCG strain has been employed for some 70 years here in Brazil and lessons from its use should be taken in account for the development or improvement of new TB vaccines. The vast majority of the current population has been vaccinated with BCG, with the possible requirement for a booster immunization in adulthood for TB protection.
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