The Fine-Grained Complexity of Median and Center String Problems Under Edit Distance

Abstract

We present the first fine-grained complexity results on two classic problems on strings. The first one is the k-Median-Edit-Distance problem, where the input is a collection of k strings, each of length at most n, and the task is to find a new string that minimizes the sum of the edit distances from itself to all other strings in the input. Arising frequently in computational biology, this problem provides an important generalization of edit distance to multiple strings and is similar to the multiple sequence alignment problem in bioinformatics. We demonstrate that for any e > 0 and k ≥ 2, an O(n^{k-e}) time solution for the k-Median-Edit-Distance problem over an alphabet of size O(k) refutes the Strong Exponential Time Hypothesis (SETH). This provides the first matching conditional lower bound for the O(n^k) time algorithm established in 1975 by Sankoff. The second problem we study is the k-Center-Edit-Distance problem. Here also, the input is a collection of k strings, each of length at most n. The task is to find a new string that minimizes the maximum edit distance from itself to any other string in the input. We prove that the same conditional lower bound as before holds. Our results also imply new conditional lower bounds for the k-Tree-Alignment and the k-Bottleneck-Tree-Alignment problems studied in phylogenetics.