Abstract

Duodenal submucosal glands occur in all mammals but show species differences both in their extent and histological structure. Surgical biopsy specimens were obtained from five individuals aged from 37 to 56 with no history of duodenal abnormality. In all cases the patient was starved for four to eight hours prior to operation and the biopsies were taken from the second part of the duodenum immediately proximal to the opening of the common bile duct. The tissue was prepared both for light and electron microscopy.By light microscopy Brunner’s glands in the human appear as masses of coiled tubules in the submucosa with ducts opening into the bases of intestinal glands. Component cells are characteristically mucous in type with dark, irregular, basally-located nuclei and clear, foamy cytoplasm.

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