Abstract
The fermented soy product ImmuBalance contains many active ingredients and its beneficial effects on some allergic diseases have been reported. We hypothesized that ImmuBalance could have potential effects on airway inflammation in a murine model of asthma. Mice sensitized and challenged with ovalbumin developed airway inflammation. Bronchoalveolar lavage fluid was assessed for inflammatory cell counts and levels of cytokines. Lung tissues were examined for cell infiltration and mucus hypersecretion. Oral administration of ImmuBalance significantly inhibited ovalbumin-induced eosinophilic inflammation and decreased Th2 cytokine levels in bronchoalveolar lavage fluid (p < 0.05). In addition, lung histological analysis showed that ImmuBalance inhibited inflammatory cell infiltration and airway mucus production. Our findings suggest that supplementation with ImmuBalance may provide a novel strategy for the prevention or treatment of allergic airway inflammation.
Highlights
IntroductionThe prevalence of allergic diseases such as asthma, rhinitis, atopic dermatitis, and food allergy, has increased globally in recent years [1,2,3,4]
We demonstrated that supplementation with the fermented soy product
We showed that ImmuBalance suppressed the Th2 cytokine levels in Bronchoalveolar Lavage Fluid (BALF) as well as OVA-specific immunoglobulin E (IgE) production in serum
Summary
The prevalence of allergic diseases such as asthma, rhinitis, atopic dermatitis, and food allergy, has increased globally in recent years [1,2,3,4]. Asthma is one of the most common allergic diseases, and is usually characterized by chronic airway inflammation. Asthma is defined by respiratory symptoms such as wheezing, shortness of breath, chest tightness, and cough that vary over time and intensity, with variable expiratory airway limitations (Global Initiative for Asthma (GINA) 2021). In patients with allergic asthma, an imbalance in lymphocyte immunity, especially between Th1 and Th2 responses, leads to immunoglobulin E (IgE) production, T cell and eosinophil infiltration, airway hyperresponsiveness, mucus cell hyperplasia, and airway remodeling, resulting in the appearance of asthma symptoms [5]. Regulation of the balance between Th1 and Th2 responses is key to controlling allergic asthma
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
