Abstract
BackgroundSoy products are associated with many beneficial health consequences, but their effects on the human intestinal microbiome are poorly characterized.ObjectivesTo identify the changes in the oral and fecal microbiome in lean and obese participants due to consumption of Q-CAN®, and to assess the expected consequences of these changes based on the published literature.MethodsProspective study of lean (10) and obese (9) participants consuming Q-CAN® twice daily for 4 weeks with 8 weeks follow-up. Microbial DNA was extracted from saliva and stool samples, amplified against the V4 region of the 16S ribosomal RNA gene and data analyzed using QIIME 1.9.1 bioinformatics. Four hundred forty-four samples were collected in total, 424 of which were productive and yielded good quality data.ResultsSTOOL. In the lean population Bifidobacteria and Blautia show a significant increase while taking Q-CAN®, and there was a trend for this in the obese population. ORAL. There were relatively fewer major changes in the oral microbiome with an increase in the family Veillonellaceae in the lean population while on Q-CAN®.ConclusionQ-CAN® consumption induced a number of significant changes in the fecal and oral microbiome. Most notably an increase in the stool microbiome of Bifidobacteria and Blautia, both of which are associated with positive health benefits, and in the saliva an increase in Veillonellaceae.Trial registrationThis trial was registered with Clinicaltrials.gov on January 14th 2016.ClinicalTrials.gov Identifier: NCT02656056
Highlights
Soy products are associated with many beneficial health consequences, but their effects on the human intestinal microbiome are poorly characterized
Most notably an increase in the stool microbiome of Bifidobacteria and Blautia, both of which are associated with positive health benefits, and in the saliva an increase in Veillonellaceae
We found that fermented soy beverage Q-CAN® alters the microbiome in lean, and healthy obese individuals, with a number of the changes occurring in a direction expected to improve overall health
Summary
Soy products are associated with many beneficial health consequences, but their effects on the human intestinal microbiome are poorly characterized. Consumption of fermented soybean foods is associated with many health benefits including reduced risks of type 2 diabetes (T2D) and blood pressure [2,3,4],. (2021) 7:6 data and using techniques that can produce results biased based on pre-existing assumptions [8,9,10,11] To overcome these limitations, we were interested in obtaining an unbiased data set of the effects of soy products on the human gastrointestinal microbiome using 16S RNA sequencing. Among the several putative ingredients of Q-CAN®, isoflavones were shown to exert several health benefits on the host via alterations in key bacteria that are associated with a beneficial effect [12]. QCAN® may restore the gut and oral microbiome and through this mechanism exert its beneficial effects
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