The feeding of diets containing up to 10% monosodium glutamate to beagle dogs for 2 years

Abstract

Beagle dogs were fed diets containing either 5.13% w/w sodium proprionate or 2.5, 5.0 or 10.0% w/w monosodium glutamate (MSG) for 104 weeks. There were no adverse effects upon bodyweight gain, economy of food consumption, general behaviour, ECG, ophthalmological findings, haematology, blood chemistry, organ weights or mortality by comparison with control dogs receiving the basal diet. Urinary volume and sodium excretion were slightly raised in dogs receiving sodium propionate or MSG, but the ability to concentrate urine was unimpaired and there were no histological differences between treated and control animals.