Abstract
Hand, foot, and mouth disease (HFMD) affects infant and young children. A viral metagenomic approach was used to identify the eukaryotic viruses in fecal samples from 29 Thai children with clinical diagnosis of HFMD collected during the 2012 outbreak. These children had previously tested negative by PCR for enterovirus 71 and coxsackievirus A16 and A6. Deep sequencing revealed nine virus families: Picornaviridae, Astroviridae, Parvoviridae, Caliciviridae, Paramyxoviridae, Adenoviridae, Reoviridae, Picobirnaviridae, and Polyomaviridae. The highest number of viral sequences belonged to human rhinovirus C, astrovirus-MLB2, and coxsackievirus A21. Our study provides an overview of virus community and highlights a broad diversity of viruses found in feces from children with HFMD.
Highlights
Hand, foot, and mouth disease (HFMD) is an infectious disease that usually affects infants and young children under 5 years of age worldwide
A number of enteroviruses belonging to the family Picornaviridae cause HFMD, human enterovirus 71 (EV71) and coxsackievirus (CV) type A16 are two of the most important enteroviruses implicated in many large-scale outbreaks in Asian-Pacific countries including Japan, Taiwan, Malaysia, Singapore, and China [2,3,4]
To evaluate circulating enterovirus and previously uncharacterized viruses associated with HFMD, we describe here the virus community in fecal samples negative by RT-PCR for EV71 and CV-A16/A6 obtained from 29 pediatric patients with HFMD during the outbreak in Thailand in 2012
Summary
Foot, and mouth disease (HFMD) is an infectious disease that usually affects infants and young children under 5 years of age worldwide. HFMD typically causes self-limiting illness, but development of severe cardiopulmonary and neurologic complications have been reported [1, 2]. A number of enteroviruses belonging to the family Picornaviridae cause HFMD, human enterovirus 71 (EV71) and coxsackievirus (CV) type A16 are two of the most important enteroviruses implicated in many large-scale outbreaks in Asian-Pacific countries including Japan, Taiwan, Malaysia, Singapore, and China [2,3,4]. Additional enterovirus species including CV-A6, CV-A10 and CV-A4 cause HFMD [5,6,7,8,9]. Clinical symptoms resulting from CV-A16 as well as other enteroviruses are usually relatively mild and indistinguishable with low incidence of severe complications.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
