Abstract
It is well known, that the injury of organs and systems and also immunological rates considerably determine clinical course and the result of brucellosis. In the article are presented the results of examination of 120 patients with acute brucellosis. The control group included 30 practically healthy persons. Groups were representative by the age and sex. The diagnosis of brucellosis was set on the base of complaints, anamnesis, epidemiological and clinical data and the results of serological examination of the blood. All patients also underwent the fixation of interleukin -6, іinterleukin-4 and TLR-2 in the blood serum. The detailed epidemiological, clinical and immunological characteristic of patients with brucellosis was presented. Among examined persons prevailed men, persons of young able-bodied persons and rural dwellers. It was revealed, that the dominating way of transmission was the contact one. The highest level of infection was fixed among the workers of farm enterprises and veterinarians. The season features were also revealed, the highest level of morbidity was in summer-autumn period. The main clinical features were: fever, arthralgia, risen disposition to perspire, hepatosplenomegaly. It was revealed, that the level of pro-inflammatory interleukins considerably prevailed over the level of anti-inflammatory ones. Despite the high sensitivity of PCR diagnostics, the positive results in our research were received only in one third of patients.
Highlights
Epidemiological and epizootic situation with brucellosis in the world remains rather strained for today, so this infectious disease remains a complicated and topical socio-economic problem for many countries
This disease flows with injury of all organs and systems that leads to the extremely unfavorable results: disablement and invalidism of patients that determines its high socio-economic significance [9]. Alongside with it brucellosis is characterized with the imbalance of cellular and humoral immunity. It is attended by the decrease of the indices of Т- and В-cellular link of immunity that results in activation of immunoglobulin (А,М,G) and essential disorders of cytokine regulation as the increase of pro-inflammatory cytokines (IL-1β, IL-6) and TLR-2 [10, 11]
Materials and methods of research We examined 120 persons with acute brucellosis, who were on the stationary treatment at infectious clinic of Baku city
Summary
Epidemiological and epizootic situation with brucellosis in the world remains rather strained for today, so this infectious disease remains a complicated and topical socio-economic problem for many countries. The important social aspect is the high specific weight of children teenagers and persona of active working age among patients with brucellosis and involvement of people who are not professionally connected with the source of possible infection in epidemiological process [7, 8]. This disease flows with injury of all organs and systems that leads to the extremely unfavorable results: disablement and invalidism of patients that determines its high socio-economic significance [9]. Тhat is why the important value is inherent to the features of epidemic process, clinical course and early diagnostics of this pathology and the study of immunological rates that allows prognosticate the severity of disease and choose the adequate pharmacotherapy
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