Abstract
Aim: To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion imaging.Method: A total of 15 healthy New Zealand rabbits received two CT scans each. The first scan (control) was acquired at 100 kV and 100 mA with iopromide (370 mg/ml), while the second scan (experimental) was acquired at 80 kV and 100 mA with iodixanol (270 mg/ml) 24 h after the first scan. The obtained images were reconstructed with filtered back projection (FBP) and AIDR-3D in the control and experimental groups respectively. The perfusion parameters (hepatic artery perfusion [HAP], portal vein perfusion [PVP], hepatic perfusion index [HPI], and total liver perfusion [TLP]) and image quality (image quality score, average CT value of abdomen aorta, signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], and figure of merit [FOM]) were compared using a paired t-test or Mann–Whitney U test between the two groups, when appropriate. The effective radiation dose and iodine intake were also recorded and compared.Results: With the exception of the FOM criteria, the image quality and perfusion parameters were not significantly different between the two groups. The effective radiation dose and iodine intake were 38.79% and 27.03% lower respectively, in the experimental group.Conclusion: Low-concentration contrast (iodixanol, 270 mg/ml) together with low tube voltage (80 kV) and AIDR-3D reconstruction help to reduce radiation dose and iodine intake without compromising perfusion parameters and image quality in liver CT perfusion imaging.
Highlights
Computed tomography perfusion imaging (CTPI) is a fast, accurate, and noninvasive functional imaging technique that reflects hemodynamic changes in the microcirculation of organs and tissues
The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were similar between the two groups (P>0.05, Table 2); the figure of merit (FOM) in the experimental group was significantly higher than the control group (P
Our data revealed that rabbits injected with iodixanol and scanned at 80 kV showed higher FOM, received a lower effective radiation dose, and experienced lower iodine intake compared with those injected c 2018 The Author(s)
Summary
Computed tomography perfusion imaging (CTPI) is a fast, accurate, and noninvasive functional imaging technique that reflects hemodynamic changes in the microcirculation of organs and tissues. This technique has been widely employed in the quantitative analysis of acute ischemic stroke in the brain [1,2,3]. To improve the image quality associated with liver CTPI, two methods are generally applied: increasing contrast agent concentration and enhancing X-ray energy. Both strategies are inappropriate in terms of patient safety.
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