The Fc Receptor-Like 3 Polymorphisms (rs7528684, rs945635, rs3761959 and rs2282284) and The Risk of Neuromyelitis Optica in A Chinese Population.

Abstract

Neuromyelitis optica (NMO) appears to be a severe inflammatory demyelinating disease occurring in the central nervous system. Furthermore, the Fc receptor-like 3 (FCRL3) gene was previously found to be susceptible for a certain inflammatory demyelinating diseases (such as multiple sclerosis). The present study, therefore, was aimed to explore the possible association of FCRL3 gene polymorphisms with susceptibility to NMO in a Chinese Han population.Seven single nucleotide polymorphisms (SNPs) of FCRL3 were, respectively, genotyped in 132 NMO patients and 264 healthy controls via PCR assay. Moreover, the t-test and the chi-square test were used to estimate the association between genetic mutations of FCRL3 and the risk of NMO with Statistical Analysis System (SAS) software (Version 9.0).It was demonstrated that FCRL3_3, 5, 6 and 8, SNPs were remarkably associated with susceptibility to NMO in both allelic [OR = 1.50 (95% CI: 1.11–2.03, P = 0.008), OR = 1.44 (1.07–1.94, P = 0.015), OR = 1.45 (1.08–1.95, P = 0.014), and OR = 2.01 (1.13–3.60, P = 0.016)] and homozygous models [OR = 2.19 (95% CI: 1.19–3.99, P = 0.010), OR = 2.09 (1.15–3.80, P = 0.014), OR = 2.04 (1.13–3.67, P = 0.016), and OR = 5.33 (1.02–27.9, P = 0.027)]. However, the other 4 SNPs, FCRL3_4, FCRL3_7, FCRL3_9, did not show the significant associations with NMO.Conclusions in the present study could be drawn that 4 SNPs in FCRL3 (FCRL3_3∗C, 5∗C, 6∗A, 8∗G) might account for increased risk of NMO in a Chinese-Han population. Nevertheless, further cohort studies are in demand to validate the association in the future.