The fate of trace elements in the brain, muscles and liver, as shown by the results of sinusostomy and angiostomy during stimulation and inhibition of the central nervous system

Abstract

Experiments were performed on sinuso- and angiostomized animals by E. S. London's method. It was established by the method of spectrochemical analysis that during the excitation of the central nervous system the content of manganese, silicone, aluminum, titanium and copper is increased in the inflowing and outflowing brian blood. There is a decrease in the difference of concentration in the arterial and venous blood and an increased content of these microelements in the cerebrospinal fluid. This shows that these elements are given of by the brain not only into the outflowing blood, but also into the cerebrospinal fluid. Inhibition of the central nervous system is connected with a distinct drop of manganese, silicone, aluminum, titanium and copper in the blood flowing from the brain and in the cerebrospinal fluid. At the same time the content of these microelements rises in the blood flowing to the brain and there is an increased difference in the concentration of these elements in the arterial and venous blood. This points to increased retention of the above mentioned microelements by the brain not only as a result of diminished release by the brain into the outflowing blood, but also into the cerebrospinal fluid. In studying the participation of other organs in increaseing the content of the above-mentioned microelements in the arterial blood it was demonstrated that during excitation the microelements are given off into the systemic circulation not only by the brain, but also by other organs (liver, muscles). Liver also releases microelements into the outflowing blood during ether anesthesia.