Abstract
THIS investigation of the tissue distribution and metabolic fate of radioactive testosterone and progesterone in mice and rats was undertaken with the primary aim of determining by animal experimentation whether the administration of a hormone containing C14 would be a serious hazard to the animal and secondarily, with the hope that experiments with rodents might provide information helpful in the study of steroid hormone metabolism in man. These considerations restricted the experimental approach to a survey rather than a detailed analysis since our principal interest was the application of tracer studies to human steroid metabolism. The major portion of the experimental work was done therefore with testosterone since the fate of this hormone in humans has been more thoroughly investigated (Dorfman, 1948; Dobriner and Lieberman, 1950). The results obtained provide a decisive answer to the primary question since it is clear that the male hormone, testosterone, and the female hormone, progesterone,
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