Abstract
Objective To investigate the factors affecting the survival and prognosis of patients with stage Ⅲ~Ⅳgastric cancers. Methods A total of 156 cases of Ⅲ~Ⅳ gastric cancer was studied retrospectively from September 1, 2006 to December 31, 2012. Kaplan-Meier analysis, Log-rank univariate analysis, Cox proportional hazards model analysis were used to analyze survival and prognostic factors. Results Twelve cases were lost, to the end of the follow-up, 22 cases were alive. The median survival time was 29.3 months. 1-year, 3-year, and 5-year overall survival rates were 83.3%, 37.8%, and 21.2%, respectively. Univariate analysis showed that tumor size, tumor node metastasis (TNM) staging, curative resection, hyperthermic intraperitoneal perfusion chemotherapy (HIPEC), and postoperative chemotherapy were correlated with prognosis (P<0.05 for all). Multivariate analysis showed that TNM staging, curative resection, HIPEC, and postoperative chemotherapy were independent prognostic factors (P<0.01 for all). Conclusions TNM staging, curative resection, hyperthermic intraperitoneal perfusion chemotherapy and postoperative chemotherapy are the independent factors affecting the prognosis of stage Ⅲ~Ⅳ gastric cancer after resection. Hyperthermic intraperitoneal perfusion chemotherapy and postoperative chemotherapy can improve their survival. Key words: Stomach neoplasms; Prognosis
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