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Abstract
Accessory subunits belonging to the KCNE family modulate voltage-gated potassium (Kv) channels such as Kv1.1, Kv1.3, Kv2.1, and Kv7.1. Incorrect modulation of potassium current through these channels have been linked to several diseases for example, long QT syndrome, allergic rhinitis, and acute lymphoblastic leukemia. Increased understanding of the molecular underpinnings of KCNE modulation of potassium channels would help expand our understanding of the etiology of these diseases. KCNE4 is unique in the KCNE family as it has been shown to inhibit current in Kv channels.
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