The expression pattern of transporters and receptors regulating the efflux of amyloid β across human blood-brain barrier

Abstract

Background: The clearance of amyloid β (Aβ) from the brain could be a novel therapeutic target for Alzheimer’s disease (AD). Although several reports demonstrate that low-density lipoprotein receptor-related protein-1 (LRP1) and ATP-binding cassette transporters were the Aβ transporters at the blood-brain barrier (BBB), conflicting data exist regarding the contribution of these proteins for the clearance of Aß through the BBB. In addition, recent reports indicate that pericytes have an important role to excrete Aβ across the BBB.