The expression of yes-associated protein in ovarian serous adenocarcinoma and clinical significance

Abstract

Objective To investigate the expressive significance of yes-associated protein(YAP) and its relationship with clinical pathological features in ovarian serous Adenocarcinoma (OSAC). Methods Forty normal and 120 OSAC patients were enrolled, whose was ovarian tissue were confirmed by pathological examination in the Central Hospital of TaiAn from January 2008 to December 2012.The expression of YAP in 120 cases of OSAC and 40 cases of normal was detected by immunohistochemically Streptavidin-peroxidase(SP) method to analyze its relationship with the clinical pathological features. Results The positive rate of YAP was higher in OSAC group (69.2%, 83/120) than that in normal ovarian tissue(7.5%, 3/40) (χ2=45.89, P<0.01). In OSAC, the expression of YAP in low level group (51.1%, 23/45) was significantly different with the high level group (80.0%, 60/75) (χ2=11.01, P<0.01). The expression of YAP in stage Ⅲ and Ⅳ group(86.9%, 20/23) was significantly different from the stage Ⅰand Ⅱgroup(64.9%, 63/97) (χ2=6.44, P<0.01). The expression of YAP in group with lymph node metastasis(88.9%, 24/27) was also significantly different from that in group without lymph node metastasis(63.4%, 59/93) (χ2=6.35, P<0.01). Conclusions YAP may participate in the process of occurrence and progression in OSAC.Detection of YAP may be an effective parameter in evaluating occurrence, progression and prognosis of OSAC, and may play an important role in early prediction of OSAC. Key words: Ovarian neoplasms; Adenocarinoma; Yes-associated protein