Abstract
Background: To explore the expression and its clinical significance of vascular endothelial growth factor receptor II and III (VEGFR2 and VEGFR3) in early gastric cancer.Methods: Immunohistochemical method is applied to detect 120 cases of early gastric cancer and normal gastric tissue of its cut edge in the expression of VEGFR2 and VEGFR3.Results: The positive expression rates of VEGFR2 and VEGFR3 in early gastric cancer are 75% and 60%, which are higher than in normal gastric tissues of cut edge (22.5%, 12.5%), respectively. The expression of VEGFR2 and VEGFR3 is associated with depth of invasion, lymph node metastasis (P 0.05).Conclusion: VEGFR2 and VEGFR3 play important roles in occurrence and development of early gastric cancer, which potentially provides a basis for targeted molecular therapy of early gastric cancer.
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