Abstract
Capsaicine (CAP), a lipophilic vanilloid substance found in Capsicum peppers which produces the sensation of heat, has a prominent excitatory action on primary afferent neurons, and has long been used as a neuropharmacological tool to identify sensitive neurons. CAP shows its effect via Vanilloid Receptor Subtype-1 (VR1). Capsaicin affects a variety of brain regions , the presence of vanillod sensitive neurons in the brain has been reported in several studies. The VR1 receptors present in the hypothalamus most likely have other important functions including regulation of body temperature, food intake, metabolic balance etc. In this study we aimed to investigate potential physiological role of VR1 receptors in reproduction. Fort his purpose we performed dual immunofluorescence staining to explore the distribution of Gonodotropin Releasing Hormone (GnRH) neurons that express VR1 in rat brain. Most VR1 positive GnRH neurons found predominantly in organum vascularis lamina terminalis and preoptic area lesser extend in medial septum diagonal band. The findings that VR1 is expressed in GnRH neurons is of great importance, it can be speculated that VR1 may have a role in reproductive axis.
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