The expression of Twist in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis

Abstract

Objective To study the expression of Twist in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis.Methods The expression of Twist and Ki-67 was detected in 60 cases with invasive ductal carcinoma of breast by immunohistochemistry.Ki-67 index and microvascular density (MVD) were calculated.Results The positive expression rate of Twist was 56.7％ (34/60) in invasive ductal carcinoma of breast.Ki-67 index and MVD in the patients with positive expression of Twist was higher than those in the patients with negative expression of Twist [(57.05 ± 16.37)％ vs.(25.32 ± 16.16)％,(34.30 ± 12.25)％ vs.(23.04 ± 10.45)％,P＜ 0.05 ].Conclusions The overexpression of Twist is found in invasive ductal carcinoma of breast.To stimulate cell proliferation and angiogenesis may be one of the pathways of Twist to contribute to the invasion and metastasis of breast cancer. Key words: Breast neoplasms; Twist protein; Ki-67 antigen; Microvascular density