The expression of scavenger receptor B2 in enterovirus 71-infected mice

Ji-An Li,Zong-Bo Chen

doi:10.7243/2050-1412-3-1

Abstract

Introduction Enterovirus 71 (EV71), a neurotropic virus with undefined pathogenesis, has caused significant morbidity and mortality throughout the world, especially in the Asia-Pacific region since it was first detected in 1969 in the United State [1,2], including Singapore [3,4], South Korea [5], Malaysia [6], Japan [7], Vietnam [8], and China [9,10].

Highlights

Enterovirus 71 (EV71), a neurotropic virus with undefined pathogenesis, has caused significant morbidity and mortality throughout the world, especially in the Asia-Pacific region since it was first detected in 1969 in the United State [1,2], including Singapore [3,4], South Korea [5], Malaysia [6], Japan [7], Vietnam [8], and China [9,10]
EV71, together with coxsackievirus A 16 (CVA16) infections are generally associated with hand, foot and mouth disease (HFMD), but EV71 infection occasionally progress to severe neurological disease, including aseptic meningitis, poliomyelitis-like paralysis, and possibly fatal encephalitis in neonates, especially brainstem encephalitis associated with pulmonary edema and cardiac insufficiency were the primary manifestations in patients with neurologic involvement [11,12]
We found that local mouse SCARB2 (mSCARB2) expression were consistent with TNF-α, IL-6 and IL-1β production in the brain, brainstem, spinal cord, cerebellum, lung and heart from EV71-infected mice

Summary

Introduction

Enterovirus 71 (EV71), a neurotropic virus with undefined pathogenesis, has caused significant morbidity and mortality throughout the world, especially in the Asia-Pacific region since it was first detected in 1969 in the United State [1,2], including Singapore [3,4], South Korea [5], Malaysia [6], Japan [7], Vietnam [8], and China [9,10]. EV71, together with coxsackievirus A 16 (CVA16) infections are generally associated with hand, foot and mouth disease (HFMD), but EV71 infection occasionally progress to severe neurological disease, including aseptic meningitis, poliomyelitis-like paralysis, and possibly fatal encephalitis in neonates, especially brainstem encephalitis associated with pulmonary edema and cardiac insufficiency were the primary manifestations in patients with neurologic involvement [11,12]. Numerous animal models have been developed to study the pathogenesis of EV71 infection using the mouse-adapted strain of EV71 [13,14], innate immunodeficient mice [15]. EV71 BrCr infected mice developed limbs paralysis and encephalitis [17]. SCARB2 ( known as Lysosomal Integral Membrane Protein II, LIMP II, LGP85 or CD36b like-2) is composed of 478 amino acids and belongs to the CD36 family, which includes CD36 and scavenger receptor B, member 1 The role of SCARB2 appears to be connected to the TNF-α-dependent and early activation of Listeria macrophages through internal signals linking the regulation of late trafficking events with the onset of the innate Listeria immune response [24]

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