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Abstract
Abstract The nucleotide-oligomerization domain (NOD) is an important molecule involved in host defense. RICK/RIP2 contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF-kB downstream of Toll-like receptors and Nod-like receptors. In order to determine the function of Nod1 and Nod2 in M. leprae infection, we measured the Nod1 and Nod2 mRNA level in tissues of nu/nu mouse infected with M. leprae. The expression of NOD1 and NOD2 mRNA was induced in tissues of nu/nu mice infected with M. leprae. In addition, the expression of inflammatory cytokines such as TNF-α and IL-1β was increased in tissues of mice infected with M. leprae, compared to those of non-infected mice. We also established HEK 293 cells to express Nod1 and Nod2 cDNA. RICK expression is, interestingly, regulated by Nod2-dependent pathway in M. leprae infection. These results suggest that NOD family proteins may have a role in the immune response to M. leprae.
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