Abstract
MARP family members CARP, Ankrd2 and DARP are expressed in the striated muscle, while DARP protein is also detected in brown adipose tissue (BAT). Taking into account recent findings concerning the common origin of muscle and brown fat, expression of CARP and Ankrd2 in mouse BAT was investigated. We demonstrated Ankrd2 expression in both inactive and thermogenically active BAT, while CARP expression was not detected. Our findings suggest that the expression of Ankrd2 in BAT could be a part of the ?myogenic transcriptional signature?, further supporting the evidence that muscle and brown adipose cells arise from the same myoblastic precursor.
Highlights
Ankyrin repeat domain protein 1 (CARP/Ankrd1), ankyrin repeat domain protein 2 (Ankrd2/Arpp) and diabetes-related ankyrin repeat protein (DARP/Ankrd23) belong to the muscle ankyrin repeat protein (MARP) family
CARP is found in skeletal muscle cells, where its level increases after eccentric exercise (Barash et al, 2004), in response to acute resistance exercise (Chen et al, 2002), work-overload hypertrophy (Carson et al, 2002) as well as in pathological conditions: Duchenne and congenital muscular dystrophies (Nakada et al, 2003a), spinal muscular atrophy (Nakada et al, 2003b) and amyotrophic lateral sclerosis (Nakamura et al, 2002)
MARP family members - CARP, Ankrd2 and DARP - are mainly expressed in striated muscle cells
Summary
LJILJANA RAKIĆEVIĆ1, NATAŠA PETROVIĆ2, DRAGICA RADOJKOVIĆ1 and SNEŽANA KOJIĆ1 1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11010 Belgrade, Serbia. 2Wenner–Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden. LJILJANA RAKIĆEVIĆ1, NATAŠA PETROVIĆ2, DRAGICA RADOJKOVIĆ1 and SNEŽANA KOJIĆ1 1Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11010 Belgrade, Serbia. Abstract - MARP family members CARP, Ankrd and DARP are expressed in the striated muscle, while DARP protein is detected in brown adipose tissue (BAT). Taking into account recent findings concerning the common origin of muscle and brown fat, expression of CARP and Ankrd in mouse BAT was investigated. We demonstrated Ankrd expression in both inactive and thermogenically active BAT, while CARP expression was not detected. Our findings suggest that the expression of Ankrd in BAT could be a part of the “myogenic transcriptional signature”, further supporting the evidence that muscle and brown adipose cells arise from the same myoblastic precursor
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