Abstract
The etiology and pathogenesis of inflammatory bowel disease (IBD) remain undetermined but an interaction between environmental, genetic and immunological factors is most widely accepted. Recent studies examine the expression of miRNAs in peripheral blood and tissues in IBD patients. Our study aims to assess and correlate the serum expression of miR-199 in IBD patients with clinical parameters such as extent, activity, and severity of the disease. A total of 35 patients with ulcerative colitis (UC) and 35 patients with Crohn’s disease (CD) were included in the study. Serum miR-199 expression in both IBD diseases was assessed using reverse transcriptase quantitative real-time PCR (RT-qPCR). Circulating miR-199 levels were also correlated with disease extent, activity, and severity indices (CDAI, Montreal classification, Partial Mayo score). Serum expression of miR-199 in the 70 patients was also compared miR-199 serum levels in 30 healthy control subjects. The patients’ group showed mean serum miR-199 expression of 2.39 for CD, 1.08 for UC, and 1.26 for the control group with significant difference in the expression between groups. From the current study, we could conclude that there is a significant correlation between increased serum expression of miR-199 and disease activity (UC), extent (CD), and severity (CD and UC).
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