The expression of Interlukin 2(IL-2), Interlukin 8(IL-8) and Interlukin 6(IL-6) in patients with oral and oropharyngeal squamous cell carcinoma in Basrah city (A case control study)

Abstract

The first part of the digestive tract is the oral mucosa, which exposed to different exogenous toxins, long period of exposure could lead to malignant changes/tumors. One of the prevalent cancers of the body is Oral squamous cell carcinoma, oral cancer sometimes may be resemble benign lesions in the mouth therefor, the diagnosis may be not easy clinically. There appear the importance of serum cytokines in distinguishing different pathologies.Aims: The aim of this study was to identify the role of serum Interlukins (IL2, IL6, IL8) in the early detection and pathogenesis of oral and oropharyngeal squamous cell carcinoma. Patients and Methods: This study included 20 patients with oral and oropharyngeal squamous cell carcinoma were clinically diagnosed and then confirmed by histopathological examination and 26 healthy control. Age, gender, as well as the level of interlukins in the serum of patients and healthy control were measured, in addition clinical signs and the site of lesions were recorded for patients group. Results: There were 20 new cases of oral and oropharyngeal squamous cell carcinoma in Basrah from September 2015 to December 2016, 12 in men and 8 in women. 26 healthy control individuals 17 men and 9 female were included in this study. Cancer at all oral sites affected men more than women. The Tongue is the most frequent site. The level of serum Interlukins (IL2, IL6, IL8) in patients group were much more than those in healthy control group.