The expression of integrin β1 and E2F1 in pathologic scars and its significance

Abstract

Objective To detect the expression of the integrin β1 and E2F1 in pathologic scars and investigate their relationship with the development of pathological scars.Methods The S-P immunohistochemistry technique was used to detect the expression levels of integrin β1 and E2F1 in pathological scars non-pathological scars and normal skin. The tatistical methods were used to investigate the relationship between integrin β1 and E2F1.Results The expression levels of integrin β1 and E2F1 had significance differences between the pathological scar group and the other two groups(P＜0.05).Th expression levels of integrin β1 and E2F1 in pathological scars had pesitivecorrelation(r=0.426).Conclusions Integrin β1 may promote the development of pathologic scar through increasing the expression of E2F1 which can avoid the fibroblast apoptosis. Key words: Pathological scars ; Integrin β1 ; E2F1 ;