Abstract
Objective: To explore the expression of IL-27, Th17 cells and CD4+CD25+ regulatory T cells (Treg) as well as its associated cytokines in peripheral blood of patients with allergic rhinitis (AR). Method: From March 2012 to May, the peripheral blood of 24 cases of AR patients (AR group) and 16 cases of healthy volunteers (control group) was collected, and the percentage of Th17 cells and Treg cells in the peripheral blood was detected by flow cytometry (FCM); the levels of IL-27, IL-17 and IL-10 in serum was detected by ELISA. Result: The percentage of Th17 cells in AR group and the control group was 1.76% ± 0.60% and 0.59% ± 0.17%, respectively. It was higher in AR group than in control group, and the difference between two groups was statistically significant (P 0.05). Conclusion: In the peripheral blood of AR patients there was a reduction of IL-27 level and imbalance of Th17/Treg cell function. IL-27 on Th17/Treg cells adjustment may play an important role on the pathogenesis of the AR.
Highlights
Allergic rhinitis (AR) is one of the most common disorders, which is characterized by sneezing, clear rhinorrhea, nasal itching and nasal congestion
From March 2012 to May, the peripheral blood of 24 cases of allergic rhinitis (AR) patients (AR group) and 16 cases of healthy volunteers was collected, and the percentage of Th17 cells and Treg cells in the peripheral blood was detected by flow cytometry (FCM); the levels of IL-27, IL-17 and IL-10 in serum was detected by ELISA
IL-27 is primarily secreted by dendritic cells, and its receptor is composed by two subunit WSX-1 and gp130
Summary
Allergic rhinitis (AR) is one of the most common disorders, which is characterized by sneezing, clear rhinorrhea, nasal itching and nasal congestion. Cytokines play an important role in the immune regulation of allergic rhinitis. They participate in the immune cell proliferation, activation, differentiation, interaction and apoptosis. IL-27 is a new member of IL-12 cytokine family It is a heterodimer composed of two subunits form of p28 and EB virus-induced gene 3 (E-pstein Barr Virus induced gene 3, EBI3). IL-27 can induce CD4+T cell proliferation, start the STAT1 pathway, induce the generation and differentiation of T-bet, and promote the differentiation of CD4+T cells to Th1; IL-27 can inhibit Th2 by decreasing GaTA3 expression. It inhibits the expression of RORγt through
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