Abstract
Objective To study the expression pattern of IFN-γ and IFN-γ receptor in the liver of biliary atresia(BA)mice.Methods Biliary atresia were induced in mice by intra-peritoneal RRV injection.Forty-five mice were of BA group and 24 mice which received 2%FCS-MEM intraperitoneal-ly were used as control The expression of IFN-γ7 and IFN-γ mRNA in livers of mice were detected with RT-PER.Results Compared to the control group,the expression of IFN-γ in the liver of BA mice at different ages was much higher,It increased first and then deereased,peaking on the 9th days after inoculating with RRv.The level was aboUt thirty times that of the control group.Meanwhile the IFN-γ R mRNA expression also increased first and then decreased,and it peaked on the 9th day.It was significantly higher than control group on the 3,6,9,14th day.The level dropped back to that of the control on the 21th day.Conclusions The expression of IFN-γ and its receptor increased almost synchronously in the livers of BA mice,a possible explanation could be receptor specific effects of in-terferon-γ on the signal transduction levels. Key words: Biliary atresha; Interferon-γ; Mice
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