Abstract

目的 研究肝细胞生长因子受体c-met在小儿疝和鞘状突的分布,增加对小儿腹股沟疝发病机制的认识.方法 2003年1月至12月,手术切除的腹股沟疝疝囊,鞘膜积液鞘膜囊和隐睾的鞘状突各20例以及10例腹膜,进行c-met免疫组化分析.结果腹股沟疝,鞘膜囊,隐睾和腹膜的间皮细胞c-met的阳性表达率分别是65%(13/20),55%(11/20),45%(9/20)和20%(2/10).各组之间差异无显著性意义(χ2=7.7,P＞0.05).各组间质细胞c-met的阳性表达率分别是85%(17/20),75%(15/20),90%(18/20)和0.腹膜间质细胞c-met的阳性表达小于其他各组(χ2=30.1,P＜0.01).平均间质细胞的分布多于间皮细胞的分布(χ2=6.65,P＜0.01).结论肝细胞生长因子受体c-met在小儿疝囊、鞘膜、隐睾和腹膜的分布没有明显差别,说明肝细胞生长因子诱导小儿疝和鞘状突的闭合作用为非特异性,以及疝囊和鞘状突的闭合调控过程和肝细胞生长因子参与调控过程的复杂性。

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