Abstract
599 Background: The assessment of the needs of the adjuvant chemotherapy has been the important problem in luminal type breast cancers. Multigene prognosis assays such as Oncotype Dx and Mammaprint, turned out to be efficient techniques. However, these assays are expensive and have not been prospectively validated. The transcription factors GATA-binding protein 3 (GATA-3) and Forkhead-box protein A1 (FOXA1) function with estrogen receptor α (ERα) in mammary morphogenesis. These transcription factors form an autoregulatory hormonal network that influences estrogen responsiveness and sensitivity to hormonal therapy. Methods: We analyzed GATA-3 and FOXA1 expression in 307 primary breast cancers by immunohistochemistry, to evaluate the association with breast cancer molecular markers, clinicopathological features and patients’ recurrence-free survival. We classified the cases into luminal A and B using hormonal receptors, HER2 and Ki67 index (cut-off value: 14%). Results: 1.GATA-3 expression was positively co...
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