Abstract
Metabolic Syndrome(MetSyn) has continuously increased in Korea for the past 10 years(KNHNES 2005).To investigate the metabolic changes of reverse cholesterol transport(RCT) as a major reason in MetSyn, 373 out‐patients were recruited from Seoul Medical Center. Clinic and biochemical measurements included anthropometry, lipid biochemistry, apo E genotyping and the expression of enzymes related to RCT such as lecithin:cholesterol acyltransferase(LCAT), cholesteryl ester transfer protein(CETP) and lipoprotein lipase(LPL).The prevalence of MetSyn was 51.3% for men and 41.8% for women using the modified criteria for ATPIII and IDF for Korea MetSyn. The levels of LCAT, apo C‐II, and apo E were increased, but the masses of CETP and LPL were decreased in MetSyn patients. CETP showed a negative correlation with BP and TG. Consequently, high LCAT and low CETP levels resulted in the MetSyn attack in concomitant with insulin resistance markers such as high TG and low LPL levels. The normal type of e3 allele showed a negative correlation with LPL and TG, and a positive correlation in variants(e2, e4) cannot be observed, apoE variants had a little effect in the lipid circulation on RCT system in MetSyn. We concluded that the increasing TG corresponding to decreased LPL and CETP activites might be considered as the potential biomarkers in the insulin resistant MetSyn patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
