Abstract
AimsTo investigate the expression of EMP1 in oral squamous cell carcinoma (OSCC) tissues and its correlation with available clinical parameters of patients with OSCC.MethodsThe mRNA levels of EMP1 were measured...
Highlights
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide.[1]
Our previous study has shown that the mRNA level of EMP1 gene decreases significantly in HNSCC samples tested by cDNA microarray.[7]
It was found that the EMP1 expression decreased significantly in oral squamous cell carcinoma (OSCC) tissues
Summary
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide.[1]. The initial events that occur in carcinogenesis are molecular changes, which could be useful if detected before the onset of symptoms and morphological changes.[4] High-throughput microarray technology allows tissues to be interrogated for identifying the expression of thousands of genes simultaneously, generating a gene-expression profile for any given cancer. It may be an efficient way to uncover the clues to the specific molecular derangements that contribute to cancer pathogenesis, and the recognition of pathognomonic alterations in gene expression may provide a basis for improved diagnosis and molecular classification of cancers.[5 6] Our previous study has shown that the mRNA level of EMP1 gene decreases significantly in HNSCC samples tested by cDNA microarray.[7]
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