Abstract
Copper-zinc superoxide dismutase (Cu/Zn-SOD), a scavenger and resolving enzyme of superoxide, an active oxygen species, has the potential to induce aging and various diseases. The present study examined the expression of Cu/Zn-SOD mRNA and the localization of Cu/Zn-SOD protein in the adult rat submandibular gland by in situ hybridization and immunohistochemistry. Both signals for Cu/Zn-SOD mRNA and immunoreactivity were recognizable in all types of ducts including intercalated, striated, granular and excretory ducts, but never in acini. The Cu/Zn-SOD-expressing cells intermingled with some duct cells that had neither a Cu/Zn-SOD mRNA expression nor immunoreaction for Cu/Zn-SOD. These findings suggest that the duct cells in the rat submandibular gland exhibit greater resistance than the acinar cells against oxidative stress.
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