Abstract
In this research, we investigated the expression of C-myc and N-ras mRNAs on 21 cases paraffin-embedded tissue sections of hepatocellular carcinoma (HCC) usingin situ hybridization technique with biotinylated labelled cDNA probes. Of 21 cases of hepatoma, C-myc mRNA was positive-expressed in 9 cases (42.9%) and N-ras positive in 4 cases (19%) in hepatoma cells, and C-myc and N-ras positive in 4 and 1 cases respectively in peritumor hepatocytes. C-myc mRNAs were localized within cytoplasms of both hepatoma cells and peritumor hepatocytes. However, the positive intensities of C-myc and N-ras mRNAs in hepatoma cells were much greater than those in peritumor hepatocytes. The results indicated that C-myc and N-ras oncogenes were overexpressed in HCC, and may play an important role in coordinatively maintaince of the malignant phenotypes in HCC.
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