Abstract
Beclin-1 is a key modulator bridging autophagy, apoptosis and differentiation. This study investigated the expression of beclin-1 in human colon cancers and its association with clinicopathological characteristics. A total of 115 cases of cancer tissues with intact follow-up data were obtained from colon cancer patients with stage IIIB. The expression of beclin-1 in cancer nest and adjacent normal tissue was examined with immunohistochemistry. The results showed the immunostaining of beclin-1 was distributed in plasma-membrane, cytoplasm and nucleus in tumor cells, which occurred in 98 cases (85.2%) of the 115 patients. No or modest beclin-1 expression was observed in adjacent non-cancerous tissues. The higher level of beclin-1 expression strongly associated with longer survival. Both univariate analysis and multivariate analysis showed that the beclin-1 expression and invasive depth of primary mass (T stage) were independent prognostic factors. Additionally, there was no significant correlation of beclin-1 expression with clinicopathological characteristics, such as sex, age, site of primary mass, pathological classification, grade, and invasive depth with the nonparametric correlation Kendall’s tau-b test．Thus, it obviously manifests that beclin-1 is a favorable prognostic biomarker in locally advanced colon carcinomas and provides the information regarding the likely targeted therapy intervention.
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