The expression of B7-H1 in thyroid papillary carcinoma and its clinical significance

Abstract

Objective To investigate the expression and clinical significance of B7-H1 in normal thyroid tissues adjacent to nodular goiter and thyroid papillary carcinoma. Methods Immunohistochemistry EnVision™ two step staining method was used to monitor tumor expression of B7-H1, its relationship with clinicopathological features was analyzed. Results The positive reaction of B7-H1 material as brown granules showed positive in cytoplasm, with occasional cell nuclear staining. Positive expression of B7-H1 in papillary thyroid carcinoma tissues 58.2% (39/67) was significantly higher than that 12.5% (2/16) of expression of B7-H1 in the normal thyroid tissues adjacent to nodular goiter. B7-H1 in thyroid papillary carcinoma score 2.94±1.843 was significantly higher than the score 0.88±1.204. (P<0.01) of B7-H1 in the normal thyroid tissues adjacent to nodular goiter. The average rank of B7-H1 expression in poorly differentiated papillary thyroid carcinoma 40.92 was significantly higher than the average rank expression in papillary thyroid carcinoma with high differentiation in 27.18 and 34.67, the average rank expression in lymph node metastasis in papillary thyroid carcinoma was significantly higher than 35.93 of the average rank expression without lymph node metastasis in papillary thyroid carcinoma (18.75, P<0.01). Conclusions The expression of B7-H1 was significantly higher in papillary thyroid carcinoma than in normal thyroid tissue, and was positively correlated with the degree of differentiation and lymph nodes. Key words: Antigens, differentiation, T-lymphocyte/ME; Thyroid neoplasms/PA; Carcinoma, papillary/PA