Abstract

Background & Objective:Prostatic carcinoma represents the second most common cancer diagnosed in men worldwide after lung cancer and the fourth common male malignancy in Egypt. Autophagy is a natural process that has both oncogenic and tumor-suppressive activities. This study aimed to evaluate the role of Beclin1 and LC3B in prostatic carcinoma. Methods: This retrospective case-control study was conducted on 110 prostate biopsies divided into three groups (55 prostatic carcinomas, 45 pure benign prostatic hyperplasias (BPH), and 10 BPH with adjacent prostatic carcinoma) retrieved from the archive of the Pathology Department, Faculty of Medicine, Menoufia University, in the period between 2017 and 2020. All biopsies were stained for Beclin1 and LC3B antibodies.Results:There was a highly significant association between higher Beclin1 and LC3B immunoreactivity score and Gleason score (score 8 and 9) (P=0.002 and 0.000, respectively). Moreover, there was a highly significant direct association between Beclin1 and LC3B expression (r=0.52, P=0.000). Also, there was a significant stepwise increase in Beclin1 positivity among the three studied groups starting from BPH to prostatic carcinoma passing through cases of BPH with neighboring tumor (P=0.000). Conclusion:From the results obtained in the present study, autophagy markers Beclin1 and LC3B showed upregulation in prostatic carcinoma. Moreover, both were associated with poor prognostic factors. So, it might be necessary to control autophagy flux in prostatic carcinoma. This might be one of the future therapeutic targets for the management of prostatic carcinoma.

Highlights

  • Prostatic carcinoma is one of the most prevalent malignant tumors of the male genital system

  • The present study aims to evaluate the immunohistochemical expression of autophagy markers Beclin1 and LC3B in prostatic carcinoma and BPH and their association with the available clinicopathological parameters

  • The present study aimed at evaluation the immunohistochemical expression of autophagy markers Beclin1 and LC3B in prostatic carcinoma and BPH and their association with the available clinicopathological parameters

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Summary

Introduction

Prostatic carcinoma is one of the most prevalent malignant tumors of the male genital system. In 2020, it was the second most common after lung cancer worldwide, accounting for 14.1% of estimated new cancer cases in males with an age-standardized world mortality rate of 7.7 per 100,000 [1, 2]. In Egypt, prostatic carcinoma is the fourth common male malignancy after liver, bladder, and lung cancers, accounting for 7.2% of estimated new cancer cases. It is considered the tenth cause of cancer deaths (2.5%) [3]. Prostatic carcinoma represents the second most common cancer diagnosed in men worldwide after lung cancer and the fourth common male malignancy in Egypt. This study aimed to evaluate the role of Beclin and LC3B in prostatic carcinoma

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