Abstract
Background: The change of expression of the -adrenergic receptor (-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model. Methods: The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of -AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction. Results: Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of -AR, -AR, and -AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P ＞ 0.05). Conclusions: These results would suggest that the subtypes of -AR in thalamus and hypothalamus may contribute to produce neuropathic pain.
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