The expression of 14-3-3β in esophageal squamous cell carcinoma tissue and the clinical significance

Abstract

Objective To investigate the expression of 14-3-3 β in esophageal squamous cell carcinoma (ESSC) tissue,and to explore the relationship between 14-3-3 β and clinicopathological factors,prognosis.Methods The 14-3-3 β expressed in tumors and adjacent normal epithelia from 78 esophageal squamous cell carcinoma patients was detected by immunohistochemical staining.Results The mild and strong expression in the nucleus of esophageal squamous cell carcinoma and adjacent tissues was 62.8％ (49/78) and 17.9％ (14/78),there was significant difference (P ＜ 0.01).The mild and strong expression in the cytoplasm of esophageal squamous cell carcinoma and adjacent tissues was 69.2％ (54/78) and 29.5％ (23/78),there was significant difference (P ＜ 0.01).The 14-3-3 β was associated with the differentiation degree of esophageal squamous cell carcinoma(P ＜ 0.01).It had nothing to do with sex,age,TNM stage,size and survival rate (P ＞ 0.05).Conclusions The expression of 14-3-3 β is significantly up-regulated in esophageal squamous cell carcinoma patients.The expression of 14-3-3 β in the nucleus and cytoplasm is higher and has positively associated with tumor differentiation degree. Key words: Esophageal neoplasms; 14-3-3β proteins; Lymph node