Abstract
The expression/methylation profile of adipogenic and inflammatory transcription factors in adipose tissue are linked to obesity related-colorectal cancer
Highlights
Colorectal cancer (CRC) is considered the most important public health concern, which constitutes the third most commonly occurring cancer worldwide in both men and women [1]
A study was in line with our results, which reported that nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) in visceral adipose tissue (VAT) was highly expressed in colorectal cancer (CRC) patients but without taking the effect of the body mass index (BMI), as we showed in our study [6]
Our results suggests that C/EBP-α, proliferator-activated receptor gamma coactivator 1-α (PGC-1α), and NF-κB are important to consider as potential biomarkers in the context of obesity and CRC, as their expression and methylation status could provide a new insight into how VAT is implicated in obesity-related CRC
Summary
Colorectal cancer (CRC) is considered the most important public health concern, which constitutes the third most commonly occurring cancer worldwide in both men and women [1]. It is well known that visceral adipose tissue (VAT) in people with obesity could produce chronic inflammation and an altered profile expression of key transcription factors that promote a favorable microenvironment to colorectal carcinogenesis [5,6]. This study showed that C/EBP-α expression enhances CRC cells migration and invasion in vitro as well as metastasis in vivo [11]. As for PPAR-γ expression, a study reported that the expression profile of PPAR-γ was significantly lower in primary tumors when compared to normal colon for CRC patients [12]. To date, there is a lack of studies of the expression profile, methylation, and functional significance in VAT of C/EBP-α and PPAR-γ in obesity-related CRC
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
