Abstract
This experiment aimed to investigate the correlation between the expressions of mir-146b and mir-221 and the proliferation, invasion, and malignancy of tumor cells. For this purpose, 135 patients with thyroid cancer treated in our hospital and 120 patients with non-malignant thyroid cancer in the outpatient clinic were selected as subjects. Fine needle biopsy tissues of the two groups were taken as samples to detect the expression levels of mir-146b and mir-221 in the tissues. The effect of the two microRNA on the proliferation and migration of cancer cells was observed by the transfection of cell lines. The contents of gal-3 and MMP9 in serum were further detected, and their relationship with the expressions of mir-146b and mir-221 was analyzed. The results showed that the expressions of mir-146b and mir-221 were significantly decreased and increased in thyroid carcinoma fine-needle aspiration tissues. Mir-146b inhibited the proliferation and migration of cancer cells, while mir-221 promoted this process. In the more cancer cells, the expression levels of these two genes changed more, and the serum levels of gal-3 and MMP9 also increased. It was concluded that the expression levels of mir-146b and mir-221 were correlated with the degree of tumor malignancy, and the low expression of mir-146b and the high expression of mir-221 were correlated with the proliferation, invasion, and malignancy of thyroid cancer tumor cells.
Highlights
Thyroid cancer (TC) is common in young and middle-aged people and is more common in women
It was concluded that the expression levels of mir-146b and mir-221 were correlated with the degree of tumor malignancy, and the low expression of mir-146b and the high expression of mir-221 were correlated with the proliferation, invasion, and malignancy of thyroid cancer tumor cells
Previous studies have shown that the expression of mir-146b and miR-221 in thyroid cancer patients' fine needle aspiration tissue has significant changes, but there are many studies to explore the correlation between the expression of mir-146b and miR-221 and tumor cell proliferation, invasion and tumor malignancy
Summary
Thyroid cancer (TC) is common in young and middle-aged people and is more common in women. To explore the relationship between microRNA and the proliferation, migration and invasion of thyroid cancer cells is helpful to analyze whether microRNA can be used as a biological marker for diagnosis; to further determine the content of tumor-related molecules such as Gal-3 and MMP9 in the serum of patients with different expression levels of microRNA can reflect the correlation between the malignant degree of the tumor with different expression levels of microRNA. Previous studies have shown that the expression of mir-146b and miR-221 in thyroid cancer patients' fine needle aspiration tissue has significant changes, but there are many studies to explore the correlation between the expression of mir-146b and miR-221 and tumor cell proliferation, invasion and tumor malignancy. This research has carried on the discussion to this question
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