Abstract
Results: The expression rates of leptin and OB-R in esophageal carcinoma were 78.8% (41/52) and 82.7% (43/52), respectively, and the rates in normal esophagus samples were 58.3% (28/49) and 59.2% (29/49), respectively. The expression rates of leptin and OB-R have statistically significant differences between esophageal carcinoma and normal esophagus tissue (P =0.027, P=0.009, P <0.05, for both). The immunostaining intensity of leptin and OB-R was significantly stronger in esophageal carcinoma than in normal esophagus tissue. The expression rates of leptin and OB-R have correlations with position, tumor size, differentiation, lymphaden metastasis, and tumor node metastasis (TNM) stage (P <0.05). Conclusion: Leptin and OB-R were dually expressed in esophageal carcinoma. They play an important role in the process of carcinogenesis and development of esophageal carcinoma.
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