Abstract
The aim of the current study was to evaluate the expression levels of STAT6, VEGF and microvessel density (MVD) score in nasal polyp tissues and to explore the underlying relationships during the pathogenesis of nasal polyps. 40 cases with surgical removal of nasal polyps were included, comparing with control group of 10 inferior turbinate mucosal tissues resected from nasal septum deviation correction surgery, from the same time period. By immunohistochemistry, the protein expression levels of STAT6, VEGF and MVD were determined. The results showed that the positive expression rate of STAT6 in mucosal epithelium and glands of nasal polyp tissues was 70%, which was significantly higher than that in control group ( P P < 0.01). The MVD values in nasal polyp group was 22.67±7.54, while 7.04±2.63 in control group. The expression of STAT6 was closely related with the expression of VEGF and MVD, increasing with the level of VEGF and MVD. In general, the expression levels of STAT6, VEGF and MVD in nasal polyp group were increased and themselves were positively correlated, indicating the significant importance in the development of nasal polyp.
Highlights
The pathology of nasal polyp is a process of imbalance between cell proliferation and apoptosis, which involves in many cytokines [1]
VEGF mainly expressed in endothelium, vascular endothelial cells, glands, mucosal cells and interstitial infiltration of inflammatory cells of nasal polyp tissues
There are 5 important functional regions located in STAT6: (1) C-terminal transcriptional activation region; (2) Tyr641 is important for IL-4 induced STAT6 activation; (3) highly conserved SH2 domain, where IL-4 receptor binding to and the region for STAT6 dimers; (4) DNA binding domain; (5) conserved N terminal region [9]
Summary
The pathology of nasal polyp is a process of imbalance between cell proliferation and apoptosis, which involves in many cytokines [1]. Regulation the proliferation and apoptosis of epithelial cells is a new way to control the chronic inflammatory reaction process [2]. STAT6, one isoform of STAT proteins, plays an important role in inflammatory regulation, and in cell proliferation, apoptosis and cancer [3,4,5]. The expression of VEGF and CD34 have been reported in nasal polyp, the role of MVD and the relationship of STAT6 and VEGF in the development of nasal polyp remain unknown. We detected the expression of STAT6 and VEGF, the value of MVD in nasal polyp tissues and analyzed the relationship between them
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