Abstract
Objective To study the changes and significance of apoprotein (Apo) A-Ⅰ, ApoA-Ⅱ and serum amyloid A protein (SAA) in patients with pneumonia. Methods One hundred patients with community acquired pneumonia were selected as pneumonia group, and the total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), ApoA-Ⅰ, ApoA-Ⅱ and SAA levels were determined before and after treatment. The indexes of patients in pneumonia group were compared with those of 30 healthy people (control group). Results There were no statistical differences in TC and HDL-C before and after treatment in pneumonia and control group (P >0.05). The ApoA-Ⅰ and ApoA-Ⅱ levels before treatment in pneumonia group were significantly lower than those in control group: (1.10 ± 0.31) g/L vs. (1.36 ± 0.21) g/L and (0.30 ± 0.04) g/L vs. (0.46 ± 0.06) g/L, the SAA was significantly higher than that in control group: (605.23 ± 118.99) mg/L vs. (3.46 ± 0.48) mg/L, and there were statistical differences (P 0.05). Conclusions In patients with pneumonia, the levels of serum TC and HDL-C have no change. However, the decrease of ApoA-Ⅰ, ApoA-Ⅱ and the increase of SAA are the important reasons for the abnormal lipid metabolism in patients with pneumonia. It is indicated that Apo plays an important role in the inflammatory response. Key words: Pneumonia; Apolipoproteins; Serum amyloid A protein
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